Pennsylvania remains a medical-only cannabis market (no adult-use retail as of late 2025), which means the “largest” operators are typically the multi-state companies that hold Pennsylvania grow/processing capacity and run some of the busiest dispensary footprints. Below are three of the most prominent operators consumers are likely to recognize in PA—plus a straight answer on who brings in the most annual revenue.
1) Green Thumb Industries (GTI) — RISE Dispensaries
Why it’s a top player: Green Thumb Industries is one of the biggest U.S. cannabis operators overall, and in Pennsylvania it’s best known through its RISE dispensary brand. The company continues to expand in-state; industry coverage around late 2025 referenced GTI opening its 19th Pennsylvania RISE location in Lebanon. (Cannabis Business Times)
Pennsylvania dispensary footprint (examples)
GTI’s official Pennsylvania listing for RISE includes locations across multiple regions of the state, such as:
- Carlisle (1186 Harrisburg Pike, Carlisle, PA 17013) (RISE Dispensaries)
- Chambersburg
- Cranberry, Erie, King of Prussia, Mechanicsburg, and others
What GTI brings to PA patients
RISE stores tend to emphasize a “pharmacy-style” retail experience—online ordering, patient support, and broad availability. For Pennsylvania consumers, GTI’s scale matters because larger operators can keep a steady flow of product variety across multiple locations, which helps reduce “out-of-stock” whiplash that smaller footprints sometimes struggle with.
Annual revenue (parent company)
Green Thumb reported $1.1 billion in total revenue for full-year 2024. (GTI Grows Investors)
2) Curaleaf — Curaleaf Pennsylvania dispensaries
Why it’s a top player: Curaleaf is one of the largest cannabis companies in the U.S. and also operates in Pennsylvania with multiple dispensary locations listed statewide on its PA dispensary page. (Curaleaf)
Pennsylvania dispensary footprint (examples)
Curaleaf’s Pennsylvania page lists several locations, including:
- Allentown (1801 Airport Road, Allentown, PA)
- Altoona (514 E Pleasant Valley Blvd., Altoona, PA)
- Bradford (109 Main Street, Bradford, PA)
What Curaleaf brings to PA patients
Curaleaf’s strength is breadth: multiple markets, a deep product bench, and strong operational consistency. In a medical-only state like Pennsylvania, that often translates into predictable access, standardized discounts/loyalty mechanics, and strong inventory planning—especially important for patients who rely on specific formats (tinctures, capsules, vapes, troches) rather than whatever is available that week.
Annual revenue (parent company)
Curaleaf reported $1.34 billion in full-year 2024 revenue. (Curaleaf Investor Relations)
3) Cresco Labs — Sunnyside dispensaries
Why it’s a top player: Cresco Labs is a major operator known for its retail brand Sunnyside, and Pennsylvania is repeatedly referenced as a core market for the company. For example, Cresco announced opening a new Sunnyside location in Chippewa Township / Beaver Falls, PA in 2025—an indicator it still sees runway in the state. (Cresco Labs Investor Relations)
Pennsylvania dispensary footprint (examples)
Cresco’s retail information highlights Sunnyside locations in Pennsylvania, including:
- Butler (201 Pillow St., Butler, PA 16001) (Cresco Labs)
- Philadelphia – Chestnut St. (1221 Chestnut St., Philadelphia, PA 19107)
- New Kensington (4 Kensington Square, New Kensington, PA 15068)
- Pittsburgh (2116 Penn Ave., Pittsburgh, PA 15222)
Sunnyside also maintains a broader “locations” directory used for store browsing and online ordering. (sunnyside.shop)
What Cresco brings to PA patients
Cresco’s edge is often described as the integration between cultivation/brands and retail execution—meaning Sunnyside stores can be tightly aligned with Cresco’s product pipeline and merchandising strategy. For patients, this can mean consistent availability of particular branded product families and a streamlined shopping approach.
Annual revenue (parent company)
Cresco reported $724 million in revenue for full-year 2024. (Cresco Labs Investor Relations)
Which company has the highest annual revenue?
Among the three companies above, Curaleaf has the highest annual revenue based on their most recently reported full-year totals:
- Curaleaf: $1.34B (FY 2024)
- Green Thumb Industries: $1.1B (FY 2024)
- Cresco Labs: $724M (FY 2024)
A quick nuance: these figures are company-wide, not Pennsylvania-only. Public cannabis operators rarely break out state-by-state revenue in a way that lets consumers confidently rank “top in PA by revenue” without making assumptions.